Oral supplementation of 300 mg daily increased mRNA levels of BRCA1 following 4 to 6 weeks of usage. 24 July 2015. Reports concerning I3C, however, provide a different story. Because there is a lack of scientific support to back up the claims that DIM can offer these benefits, however, it may be best to speak with your doctor first. Dent P. Crosstalk between ERK, AKT, and cell survival. 20 to 50 milligrams of DHEA supplements are safe for people over the age of 30, according to the National Institute of Health. DIM may lead to positive -- or negative -- effects on various types of hormone-sensitive cancers. That’s why DIM is believed to help protect prostate tissue from the possible development of prostate cancer. What Does Dim Do For a Woman? Across all of these studies, there have been only two cases where asymptomatic hyponatremia resulted. Thus, it stands to reason that if you take a good DIM supplement, you might avoid putting on as much weight. What is the best DIM dosage?In clinical settings, taking DIM supplements of up to 300 milligrams daily is considered possibly safe.In some rare cases, gastrointestinal upset and/or headaches have been reported.These side effects were short-lived and generally mild.Supplementation with DIM is recommended for less than twelve weeks of duration.For certain therapeutic uses, DIM dosages of 600 milligrams daily and more have been tested. For one, bad estrogens signal to your body to hold onto weight, especially in the hips ans thighs. ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Here are a few of my favorites: Cortisol Manager: You need 7 to 8.5 hours of sleep to break through weight loss resistance. Diindolylmethane is a naturally occurring substance that can greatly enhance your overall health. Purpose: Your reason for needing more DIM may change the supplement dosage. Weight Loss. PMC. I have since lowered my doses after 2 months of this. 2 DIM by smokey mountain naturals one morning one night. Using DIM for acne is different from using it for weight loss, for anticancer effects, to improve depression, or to help with menopause symptoms. All forms of cabbage. I would recommend only taking 2 if your estrogen dominance is severe and only for 1 month. After that lower to 1 a day. If you have more ‘good’ estrogen and balanced hormones in general, your metabolism will be higher. These “good” metabolites are also important to overall health because they contain important antioxidant activity that can explain why estrogen in women can slow the progress of some age-related diseases such as arthritis, heart disease and cancer (x). DIM-plus Dosage. Finally, DIM seems to exhibit both estrogenic and antiestrogenic effects in clinical tests. The efficacy of doses greater than 300 milligrams per day has not been established, and some reports of nausea or headache have been reported above that threshold. Proponents claim that consuming diindolylmethane can help increase your defense against several types of cancer, as well as promote detoxification and support weight loss. It is possible that these “good” metabolites help lower the risk of cancer and decrease the symptoms of estrogen over-stimulation, which can include growing uterine fibroid tumors, breast tenderness, cervical problems and endometriosis (x). Always consult your doctor before adding any supplement to your diet and remember to read directions on product labels before use (x). Postmenopausal women sometimes take just 50 or 75 mg per day. My favorite supplement for... Berberine is the most proven supplement to reset insulin and support weight loss in women. The typical clinical trial uses between 150 and 300 mg of DIM, taken all at once. Graduate of Longwood University in Virginia. Cancer Biol Ther. BENEFITS FOR WOMEN Our DIM supplement may provide the following benefits: estrogen dominance, relief from negative physical effects of menopause, PCOS relief, mood balancing, mental clarity, and weight loss support. For certain therapeutic uses, DIM dosages of 600 milligrams daily and more have been tested. Concerning breast cancer, diindolylmethane administration has demonstrated the following in research studies: In one 250-day murine study, spontaneous tumor growth was reduced by more than 45% following DIM administration. The key to adding diindolylmethane to your nutrition routine, though, is to stick with what we know. 2014 Apr 3;33(14):1828-39. doi: 10.1038/onc.2013.122. The primary alternative to taking DIM Plus is eating vegetables high in DIM, such as: Turnips. Web. At low doses between two and twenty-four milligrams daily, diindolylmethane supplementation seems to be quite safe for children, babies, pregnant women and new moms who are nursing. Most notably broccoli, kale, and cauliflower. Your lifestyle and not following the diet plan properly can be the cause of weight gain. Essentially, it can be helpful in keeping the hormones in check and in balance. Accumulating more bodyfat is one consequence of having too much estrogen. Bok choy. However, signs are encouraging. However, it’s best to take about 100 mg (1/16 tsp) or 200 mg (scant 1/8 tsp) once or twice daily. Supplementation with DIM is recommended for less than twelve weeks of duration. Across all of these studies, there h… "Journal of cellular physiology 219.1 (2009): 94–99. Thyroid Support by 1 body 2 in morning. The usual dose of bioavailable, micro-encapsulated DIM for women is 100 to 200 mg per day taken with food. Carcinogenesis. 2004 Mar; 9(1): 76–87. Research also shows that DIM contains strong anticancer properties (x). 24 July 2015. DIM can treat acne because it affects testosterone, which has a connection to acne. DIM is the most studied of all 13C metabolites and is being studied as a chemo-protective compound for certain types of cancer (x). It is used in association with carbohydrate restriction and exercise. The study found that adding DIM to the treatment plan may in fact lead to a better outcome (x). Vitex (Chaste tree berry) For centuries, Greek and Italian medicine has considered Vitex to be … Diindolylmethane may cause a decrease in the amount of sodium in the body (x). Typical doses for premenopausal women with symptoms of estrogen dominance, which include breast pain, painful periods, excessive periods, and PMS, are from 150 to 300 mg per day. There are no known negative interactions between diindolylmethane supplements and other plant-based remedies or foods. However, this supplement has not yet been approved by the FDA for the treatment of cancer.